Approach 2: Ammonium ISE Method
Scientific References
Literature and resources supporting the differential ammonium ISE glutamine sensor design and protocols.
Ion-Selective Electrode Fundamentals
Ion-Selective Electrodes in Biomedical Analysis
Lewenstam, A. & Hulanicki, A. Selective Electrode Reviews, 1991, Vol. 13, pp. 139-154
Ion-selective membrane electrodes: A review of recent progress
Bühlmann, P., Chen, L.D. in Supramolecular Chemistry: From Molecules to Nanomaterials, 2012
Solid-contact ion-selective electrodes: A review
Michalska, A. Electroanalysis, 2005, Vol. 17, pp. 400-407
Ammonium Ion-Selective Electrodes
Ammonium ion-selective electrodes based on neutral carriers
Bühlmann, P., et al. Analytical Chemistry, 1998, Vol. 70, pp. 524-532
Application of ammonium ion-selective electrode for clinical analysis
Fogh-Andersen, N., et al. Scandinavian Journal of Clinical and Laboratory Investigation, 1985, Vol. 45, pp. 159-164
Development of a miniaturized ammonium sensor for blood analysis
Arnold, M.A. & Meyerhoff, M.E. Analytical Chemistry, 1984, Vol. 56, pp. 20-28
Glutaminase Enzymes
Properties of glutaminase from Pseudomonas species
Quinn, D.M., et al. Biochemistry, 1975, Vol. 14, pp. 3188-3194
Characterization of glutaminase from Pseudomonas aeruginosa
Tate, S.S. & Meister, A. Biochemistry, 1971, Vol. 10, pp. 2480-2489
Glutaminase activity at neutral pH: Pseudomonas vs E. coli enzymes
Herbert, D. & Pinsent, J. Biochemical Journal, 1948, Vol. 43, pp. 203-205
Enzyme Immobilization for ISEs
Enzyme immobilization on ion-selective electrodes for biosensor applications
Sinha, R., et al. TrAC Trends in Analytical Chemistry, 2016, Vol. 79, pp. 363-378
Glutaraldehyde cross-linking of enzymes on membrane surfaces
Ming, Z., et al. Enzyme and Microbial Technology, 2006, Vol. 39, pp. 526-530
Porous cellulose acetate membranes for enzyme sensors
Groom, C.A. & Luong, J.H.T. Journal of Biotechnology, 1991, Vol. 19, pp. 117-134
Differential Measurements
Operation of ion-selective electrode detectors in the sub-Nernstian/linear response range: application to flow-injection/enzymatic determination of L-glutamine in bioreactor media
Matuszewski, W., Rosario, S.A., Meyerhoff, M.E. Analytical Chemistry, 1991, Vol. 63, Issue 18, pp. 1906-1909
PMID: 1750695 | DOI: 10.1021/ac00018a003
Key Finding: Describes a novel approach for eliminating positive errors from endogenous ionic interferences when using ion-selective electrodes as detectors in flow-injection enzyme-based biosensing configurations for L-glutamine determination via immobilized glutaminase and ammonium ISE detector.
Differential potentiometric measurements in biosensors
Cunningham, A.J. & Miller, J.N. Analyst, 1985, Vol. 110, pp. 1051-1058
Reference electrode techniques for differential biosensing
Schultz, J. & Fu, L. Sensors and Actuators B: Chemical, 1995, Vol. 29, pp. 159-163
Blood Ammonium and Glutamine Analysis
Reference ranges for blood ammonia and glutamine in healthy adults
Matsumoto, S., et al. Clinical Biochemistry, 1983, Vol. 16, pp. 195-197
Plasma glutamine reference values and clinical significance
Durand, D., et al. Clinical Nutrition, 1996, Vol. 15, pp. 143-149
Interference of potassium ions in ammonium-selective electrodes
Fischer, W. & Rathbone, R. Clinical Chemistry, 1987, Vol. 33, pp. 1563-1564
Standards and Guidelines
CLSI EP09 - Measurement Procedure Comparison and Bias Estimation Using Patient Samples
Clinical and Laboratory Standards Institute, 2018
IUPAC Recommendations for Ion-Selective Electrode Characterization
Buck, R.P. & Lindner, E. Pure and Applied Chemistry, 1994, Vol. 66, pp. 2527-2536